Masahiro Nakatochi

The paper develops a model to assess genetic and epigenetic contributions to plasma lipid levels and finds that combining rare variants, PRS, and MRS improves LDL-C prediction.

This study identifies twelve novel blood pressure loci and shows smoking modifies genetic effects on BP through immune-related pathways in over 1 million individuals.

This study identifies dysregulated synaptic gene expression in oligodendrocytes of SBMA mice, highlighting early cell-to-cell communication changes as a potential therapeutic target.

This study shows that locally produced C3 in cancer-associated fibroblasts, not circulating C3, determines immune checkpoint blockade efficacy by modulating myeloid cell infiltration.

The paper identifies dysregulated expanded endocannabinoid system metabolites in ALS and shows FAAH inhibition improves motor neuron degeneration in models.

This study identifies 1,289 genetic signals for type 2 diabetes in 2.5 million individuals, revealing distinct clusters linked to vascular complications and highlighting ancestry-specific genetic risk factors.

The paper identifies common genetic variants for sleep duration across multiple ancestries and finds shared genetic effects in diverse populations.

This study identifies 277 T2D loci using diverse populations and improves fine-mapping to assess causal genes and mechanisms, enhancing clinical translation.

This study identifies 242 genetic loci for glycaemic traits using trans-ancestry meta-analysis, finding 99 novel loci and improved fine-mapping resolution compared to single-ancestry analyses.

This paper identifies 56 new type 2 diabetes loci in 433,540 East Asian individuals through a meta-analysis of GWAS data.