A novel DNA repair protein, N-Myc downstream regulated gene 1 (NDRG1), links stromal tumour microenvironment to chemoresistance
Nina V. Kozlova, Kayla A. Cruz, Hanna M. Doh, Antoine A. Ruzette, Nicholas A. Willis, Su Min Hong, Raul S. González, Monika Vyas, Laura M. Selfors, Stephan B. Dreyer, Rosanna Upstill‐Goddard, Kerrie L Faia, Steve Wenglowsky, Joshua Close, Alica K. Beutel, , Taru E. Muranen
This study identifies NDRG1 as a DNA repair protein that links pancreatic cancer stroma to chemoresistance by enhancing DNA damage repair through R-loop resolution.
bioRxiv · Jan 22, 2025 · PreprintCancer Biology