Stephan B. Dreyer

This study traces the clonal evolution of pancreatic cancer from IPMN using genomic and transcriptomic data, identifying two distinct evolutionary trajectories and their implications for PDAC progression.

This study identifies architectural subtypes of PDAC using morphospatial profiling of CAFs, showing improved prognostication and chemotherapy response prediction.

This study shows that sequential ATR and PARP inhibition can overcome acquired resistance to DNA damaging agents in pancreatic ductal adenocarcinoma.

This study identifies NDRG1 as a DNA repair protein that links pancreatic cancer stroma to chemoresistance by enhancing DNA damage repair through R-loop resolution.