Lipid-rich ascites reprograms T cell lipid metabolic transcriptome to drive dysfunction
Peter Kok-Ting Wan, Gülşah Albayrak, Luke Furtado O’Mahony, Kerry Fisher, L. A. Seymour
This paper shows that lipid-rich ascites alters T cell metabolism, leading to dysfunction, and that removing lipids restores T cell function and enhances BiTE therapy.
bioRxiv · Mar 13, 2026 · PreprintCancer Biology