Cancer BiologybioRxivPreprint
Lipid-rich ascites reprograms T cell lipid metabolic transcriptome to drive dysfunction
Peter Kok-Ting Wan, Gülşah Albayrak, Luke Furtado O’Mahony…·L. A. Seymour
This paper shows that lipid-rich ascites alters T cell metabolism, leading to dysfunction, and that removing lipids restores T cell function and enhances BiTE therapy.
DOI 10.64898/2026.03.11.711101