Hotspot KRAS mutations in brain metastases at the first metastatic recurrence of cutaneous melanoma
Roy Rabbie, Peter M. Ferguson, Kim Wong, Dominique‐Laurent Couturier, Una Moran, Clinton P. Turner, Patrick O. Emanuel, Kerstin Haas, Jodi M. Saunus, Morgan R. Davidson, Sunil R. Lakhani, Brindha Shivalingam, Georgina Venetia Long, Christine Parkinson, Iman Osman, , David J. Adams
This study identifies hotspot KRAS mutations as enriched in early brain metastases of melanoma, associated with worse survival and clonal origin, suggesting potential for risk stratification.
British Journal of Cancer · Oct 6, 2020Peer-reviewedGenomics