Iman Osman

Melanoma evolution in the lymph node shapes systemic outcomes

This study shows that lymph nodes actively drive melanoma evolution and immune evasion, linking regional metastasis to poor patient outcomes.

Patient-derived IgG Amplifies Fcγ Receptor-Dependent Colonic Inflammation During Immune Checkpoint Blockade

The paper shows that patient-derived IgG from those with severe immune-related colitis amplifies inflammation during immune checkpoint blockade in humanized FcγR mice.

Lymphatic egress recycles tumor-experienced effector CD8 T cells to sustain immune surveillance

The paper identifies a lymphatic circuit that sustains stem-like CD8+ T cells by recycling tumor-experienced effector T cells, enhancing immune surveillance and ICB response.

Gut microbiome is associated with recurrence-free survival in patients with resected Stage IIIB-D or Stage IV melanoma treated with immune checkpoint inhibitors

The paper identifies gut microbiome taxonomic markers associated with recurrence in melanoma patients treated with immune checkpoint inhibitors, showing generalizability across regions when GMB composition is matched.

Chromatin architecture and physical constriction cooperate in phenotype switching and cancer cell dissemination

This study shows that chromatin architecture and physical constriction together drive phenotype switching and metastasis in melanoma by altering CTCF positioning and heterochromatin structure.

A targetable developmental program co-regulates angiogenesis and immune evasion

This study identifies HOXD13 as a driver of a developmental program in melanoma that promotes angiogenesis and suppresses T-cell infiltration through a gene regulatory axis involving VEGFA, SEMA3A, and CD73.

IFNγ-dependent metabolic reprogramming restrains an immature, pro-metastatic lymphatic state in melanoma

This study shows that IFNγ suppresses lymphatic vessel growth and metastasis by altering metabolism and immune function in melanoma.

NF1 Loss Remodels Tumor Niches for Immune Evasion

This study identifies immune niches in NF1 mutant melanoma that promote immune evasion and shows EGFR inhibition can restore immune responses.

Integrated in vivo functional screens and multi-omics analyses identify alpha-2,3-sialylation as essential for melanoma maintenance

CRISPR-inhibition screen for lncRNAs linked to melanoma growth and metastasis

The paper identifies lncRNAs involved in melanoma growth and metastasis using CRISPR-inhibition screens and validates their functional roles.

The carnosinase dipeptidase CNDP1 is a novel metabolic vulnerability in brain metastasis

This study identifies CNDP1 as a metabolic vulnerability in brain metastasis, showing its inhibition suppresses metastasis and its expression confers metastatic potential.

Hotspot KRAS mutations in brain metastases at the first metastatic recurrence of cutaneous melanoma

This study identifies hotspot KRAS mutations as enriched in early brain metastases of melanoma, associated with worse survival and clonal origin, suggesting potential for risk stratification.