Christine Parkinson

This paper develops a gene expression signature, Cam_121, to predict long-term outcomes in primary melanoma patients, showing improved accuracy compared to clinical and existing prognostic models.

This study identifies hotspot KRAS mutations as enriched in early brain metastases of melanoma, associated with worse survival and clonal origin, suggesting potential for risk stratification.

The paper analyzes whole-genome sequencing data from melanoma metastases to show that branched evolution is common and that subclonal heterogeneity is prevalent in metastatic melanoma.

The paper shows that selecting short DNA fragments in plasma improves the detection of circulating tumour DNA by enriching mutated DNA, enabling identification of copy number alterations previously undetected.