Disruption of Hepatocyte Jak2 leads to Spontaneous NASH in Aged Mice and Uncouples Metabolic Liver Disease from Insulin Resistance
Camella G. Wilson, Aras N. Mattis, Jennifer L. Tran, Kevin Corbit, Ethan J. Weiss
This paper shows that disrupting Jak2 in hepatocytes causes spontaneous NASH in aged mice without dietary changes, while adipocyte Jak2 loss improves insulin sensitivity.
bioRxiv · Oct 4, 2016 · PreprintPhysiology