CRISPR with Transcriptional Readout reveals influenza transcriptionis modulated by NELF and can precipitate an interferon response
Alison C. Vicary, Sydney NZ Jordan, Marisa Mendes, Sharmada Swaminath, Lennice K. Castro, Justin S. Porter, Kevin D. Vo, Alistair B. Russell
The paper introduces CRITR-seq, a CRISPR-based method to measure transcriptional effects, and identifies NELF as a regulator of influenza transcription and interferon response.
Proceedings of the National Academy of Sciences · Aug 27, 2025Peer-reviewedMolecular Biology