Author

Lennice K. Castro

University of California San DiegoORCID 0000-0001-6115-6883Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Molecular Biology· 2

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 2 Research Focus:benchmarking· 1 Assay:CRISPR screen· 1 Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1 Research Focus:perturbation response prediction· 1

Frequent Co-Authors

Alison C. VicaryiD· 1 shared Alistair B. RusselliD· 1 shared John D. GrossiD· 1 shared Justin S. Porter· 1 shared Kevin D. Vo· 1 shared Li YupingiD· 1 shared Marisa MendesiD· 1 shared Matthew D. DaughertyiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

1 shared paperMolecular Biology

Alison C. VicaryORCID

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

Molecular BiologyCell ReportsPeer-reviewedJun 23, 2026

Structure of the E3 ligase CRL2-ZYG11B with substrates reveals the molecular basis for N-degron recognition and ubiquitination

Xi Liu, Li Yuping, Lennice K. Castro…·John D. Gross

The paper presents Cryo-EM structures of the CRL2-ZYG11B complex with substrates, revealing how ZYG11B recognizes and ubiquitinates Gly/N-degrons to activate the NLRP1 inflammasome.

1 citation

experimental assay

𝕏 PostBluesky

Molecular BiologyProceedings of the National Academy of SciencesPeer-reviewedAug 27, 2025

CRISPR with Transcriptional Readout reveals influenza transcriptionis modulated by NELF and can precipitate an interferon response

Alison C. Vicary, Sydney NZ Jordan, Marisa Mendes…·Alistair B. Russell

The paper introduces CRITR-seq, a CRISPR-based method to measure transcriptional effects, and identifies NELF as a regulator of influenza transcription and interferon response.

3 citations

humanCRISPR screen

𝕏 PostBluesky