Marisa Mendes

This study identifies mutations disrupting the polyuracil tract in influenza delVGs that significantly enhance interferon production and suppress replication-competent virus growth.

The paper introduces CRITR-seq, a CRISPR-based method to measure transcriptional effects, and identifies NELF as a regulator of influenza transcription and interferon response.

The paper identifies NS2-dependent sequence requirements beyond canonical promoters for efficient influenza A virus genome replication, explaining divergent transcriptional dynamics across viral segments.

This study identifies a novel IAV RNA species, capped complementary RNAs (ccRNAs), which hybridize with viral RNA to activate RIG-I, revealing an alternative mechanism for innate immune activation during IAV infection.

This paper introduces CREATE, a genetic circuit platform that enables complex signal processing in mammalian cells through programmable transcription factors and site-specific recombination.