NRBP1 and TSC22D proteins impact distal convoluted tubule physiology through modulation of the WNK pathway
Germán Ricardo Magaña-Ávila, Héctor Carbajal‐Contreras, Ramchandra Vijay Amnekar, Toby A. Dite, Michelle Téllez-Sütterlin, Kevin García-Ávila, Brenda Marquina‐Castillo, Alejandro Lopez Saavedra, Norma Hilda Vázquez, Eréndira Rojas‐Ortega, Eric J. Delpire, David H. Ellison, Dario R. Alessi, Gerardo Gamba, María Castañeda‐Bueno
This study shows NRBP1 and TSC22D proteins modulate WNK signaling in the kidney's distal convoluted tubule, affecting Na+ reabsorption through NCC phosphorylation.
Science Advances · Jul 16, 2025Peer-reviewedPhysiology