Author

Gerardo Gamba

Instituto Nacional de Ciencias Médicas y Nutrición Salvador ZubiránORCID 0000-0002-4378-9043Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cell Biology· 1 Genetics· 1 Molecular Biology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:cell signaling & trafficking· 2 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:host-pathogen & immune response· 1 Organism:mouse· 1 Research Focus:protein folding & dynamics· 1 Assay:protein structure· 1

Frequent Co-Authors

María Castañeda‐BuenoiD· 3 shared Dario R. AlessiiD· 2 shared Eréndira Rojas‐OrtegaiD· 2 shared Germán Ricardo Magaña-ÁvilaiD· 2 shared Héctor Carbajal‐ContrerasiD· 2 shared Norma Hilda VázqueziD· 2 shared Adrián Rafael Murillo‐de‐OzoresiD· 1 shared Adriana MercadoiD· 1 shared

Activity by Year

2019-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 28 mutual co-author links

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Focal author (center)Selected co-authorORCID co-authorUnlinked name

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3 shared papersCell Biology

María Castañeda‐BuenoORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Determinants of CCT motif specificity in WNK signaling and expansion of CCT like domains

Germán Ricardo Magaña-Ávila, Eréndira Rojas‐Ortega, Mario Saul Lira-Castañeda, Ivan Diaz-Ortiz, Juan Bustamante, Héctor Carbajal‐Contreras, Esteban Rojas-Juarez, Regina Ortega-Prado, Alejandro Márquez‐Salinas, Norma Hilda Vázquez, Gerardo Gamba, María Castañeda‐Bueno

The paper identifies a new motif recognized by WNK CCT domains and shows that interaction specificity is determined by physicochemical features rather than strict sequence conservation.

bioRxiv · Apr 17, 2026 · PreprintCell Biology

NRBP1 and TSC22D proteins impact distal convoluted tubule physiology through modulation of the WNK pathway

Germán Ricardo Magaña-Ávila, Héctor Carbajal‐Contreras, Ramchandra Vijay Amnekar, Toby A. Dite, Michelle Téllez-Sütterlin, Kevin García-Ávila, Brenda Marquina‐Castillo, Alejandro Lopez Saavedra, Norma Hilda Vázquez, Eréndira Rojas‐Ortega, Eric J. Delpire, David H. Ellison, Dario R. Alessi, Gerardo Gamba, María Castañeda‐Bueno

This study shows NRBP1 and TSC22D proteins modulate WNK signaling in the kidney's distal convoluted tubule, affecting Na+ reabsorption through NCC phosphorylation.

Science Advances · Jul 16, 2025Peer-reviewedPhysiology

Sequence and structural variations determining the recruitment of WNK kinases to the KLHL3 E3 ligase

Zhuoyao Chen, Jinwei Zhang, Adrián Rafael Murillo‐de‐Ozores, María Castañeda‐Bueno, Francesca D’Amico, Raphael Heilig, Charlotte E. Manning, F.J. Sorrell, Vincenzo D’Angiolella, Román Fischer, Monique P. C. Mulder, Gerardo Gamba, Dario R. Alessi, Alex N. Bullock

This paper determines the crystal structure of KLHL3 in complex with a WNK3 peptide, revealing structural features and phosphorylation-dependent regulation of WNK3 binding.

Biochemical Journal · Feb 18, 2022Peer-reviewedMolecular Biology

Integrated K+ channel and K+-Cl- cotransporter functions regulate fin proportionality in zebrafish

Jennifer S. Lanni, David S. Peal, Laura J. Ekstrom, Hai‐Ning Chen, Caroline R. Stanclift, Margot E. Bowen, Adriana Mercado, Gerardo Gamba, Kristopher Thomas Kahle, Matthew P. Harris

The paper identifies a zebrafish mutant with proportional overgrowth due to Kcc4a loss of function and shows its role in bioelectric signaling for growth regulation.

bioRxiv · Apr 28, 2019 · PreprintGenetics