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Kevin H. Liu

Baker Heart and Diabetes Institute

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Physiology· 1

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Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Organism:mouse· 1

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Aaron W JurrjensiD· 1 shared Aleksandra FilipovskaiD· 1 shared Anna C. CalkiniD· 1 shared Aowen ZhuangiD· 1 shared Artika P. NathiD· 1 shared Brian G. DrewiD· 1 shared Christine YangiD· 1 shared Danielle L. RudleriD· 1 shared

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1 shared paperPhysiology

Aaron W JurrjensORCID

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1 paper

Recent·Most cited

PhysiologyNature CommunicationsPeer-reviewedMar 8, 2025

Skeletal Muscle Specific PolG Dysfunction Activates the Integrated Stress Response and Promotes a Cachexia like Phenotype

Simon T. Bond, Emily J. King, Shannen Walker…·Brian G. Drew

This study shows that muscle-specific PolG dysfunction causes mitochondrial dysfunction and cachexia by activating the mtISR and altering the mitochondrial folate cycle.

25 citationstop 2%

mousebulk RNA-seq

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