Author

Danielle L. Rudler

The Kids Research Institute AustraliaORCID 0000-0002-5540-6548Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioinformatics· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Approach:experimental assay· 2 Research Focus:benchmarking· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:dimensionality reduction· 1 Research Focus:gene regulatory network inference· 1 Assay:long-read sequencing· 1

Frequent Co-Authors

Aaron W JurrjensiD· 1 shared Aleksandra FilipovskaiD· 1 shared Alice CleyneniD· 1 shared Anna C. CalkiniD· 1 shared Aowen ZhuangiD· 1 shared Artika P. NathiD· 1 shared Brian G. DrewiD· 1 shared Christine YangiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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1 shared paperPhysiology

Aaron W JurrjensORCID

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2 papers

Recent·Most cited

T2G: fast and accurate transcriptome to genome BAM liftover for short and long read RNA sequencing

Danielle L. Rudler, Shafi Mahmud, Alice Cleynen, Nikolay E. Shirokikh

T2G converts transcriptome-aligned BAM files to genome coordinates, improving specificity and splice junction accuracy across RNA sequencing technologies.

bioRxiv · Oct 21, 2026 · PreprintBioinformatics

Skeletal Muscle Specific PolG Dysfunction Activates the Integrated Stress Response and Promotes a Cachexia like Phenotype

Simon T. Bond, Emily J. King, Shannen Walker, Christine Yang, Yingying Liu, Kevin H. Liu, Aowen Zhuang, Aaron W Jurrjens, Haoyun Fang, Luke E. Formosa, Artika P. Nath, Sergio Ruiz Carmona, Michael Inouye, Thy Duong, Kevin Huynh, , Brian G. Drew

This study shows that muscle-specific PolG dysfunction causes mitochondrial dysfunction and cachexia by activating the mtISR and altering the mitochondrial folate cycle.

Nature Communications · Mar 8, 2025Peer-reviewedPhysiology