Artika P. Nath

An Injectable Antisense Oligonucleotide (ASO) Approach to Treat Obesity in Preclinical Models

This paper demonstrates that injectable antisense oligonucleotides (ASO) can prevent and treat obesity in mice without significant loss of lean mass.

Skeletal Muscle Specific PolG Dysfunction Activates the Integrated Stress Response and Promotes a Cachexia like Phenotype

This study shows that muscle-specific PolG dysfunction causes mitochondrial dysfunction and cachexia by activating the mtISR and altering the mitochondrial folate cycle.

Genetic determinants of blood gene expression and splicing and their contribution to molecular phenotypes and health outcomes

This study identifies genetic determinants of blood gene expression and splicing, linking them to molecular phenotypes and health outcomes through QTL analysis and colocalization.

Whole blood transcriptional profiles and the pathogenesis of tuberculous meningitis

This study identifies gene modules, hubs, and pathways associated with TBM mortality using whole blood RNA sequencing and develops a 4-gene biomarker for predicting death from TBM.

Misexpression of inactive genes in whole blood is associated with nearby rare structural variants

The paper identifies misexpression of inactive genes in whole blood and links it to nearby rare structural variants using RNA and genome sequencing data.

An atlas of genetic scores to predict multi-omic traits

The paper develops genetic scores for 17,227 molecular traits using multi-omic data from INTERVAL and validates them across ancestries, demonstrating their utility in pathway analysis and disease association discovery.

Genetically personalised organ-specific metabolic models in health and disease

The paper develops genetically personalised organ-specific metabolic models to identify associations between metabolic fluxes and disease risk, finding 97 fluxes linked to coronary artery disease.

Multivariate genome-wide association analysis of a cytokine network reveals variants with widespread immune, haematological and cardiometabolic pleiotropy

This study identifies genetic variants with pleiotropic effects on cytokines and related traits using a multivariate genome-wide association analysis.

Elevated alpha-1 antitrypsin is a major component of GlycA-associated risk for future morbidity and mortality

The paper identifies alpha-1 antitrypsin as a key contributor to GlycA's predictive power for disease risk and mortality across multiple conditions.

Genomic analysis of Mycobacterium tuberculosis reveals complex etiology of tuberculosis in Vietnam including frequent introduction and transmission of Beijing lineage and positive selection for EsxW Beijing variant

An interaction map of circulating metabolites, immune gene networks and their genetic regulation

The paper integrates transcriptomic, metabolomic, and genomic data to identify gene networks and their genetic regulation linked to immune function and circulating metabolites.