Dynamics of the HD regulatory subdomain of PARP 1; substrate access and allostery in PARP activation and inhibition.
Tom E. H. Ogden, Ji‐Chun Yang, Marianne Schimpl, Laura E. Easton, Elizabeth Underwood, Philip B. Rawlins, Michael McCauley, Marie-France Langelier, John M. Pascal, Kevin J. Embrey, David Neuhaus
This study investigates the dynamics of the HD subdomain in PARP-1 using NMR and crystal structures to understand its role in activation and inhibition.
Nucleic Acids Research · Jan 9, 2021Peer-reviewedMolecular Biology