John M. Pascal

The paper identifies PPRD1 and DAPX1 as key components of the deamination-editing machinery in Diplonema papillatum, showing their role in C-to-U and A-to-I RNA editing across multiple sites.

The paper shows that TraE and TraD, inner membrane proteins of the T4SS, bind DNA and identifies potential targets for conjugation inhibitors.

This study identifies structural differences in PARP1 and PARP2 activation mechanisms, showing that PARP2 requires an active site alpha-helix to be unfolded for DNA damage-induced activation, unlike PARP1.

This study investigates the dynamics of the HD subdomain in PARP-1 using NMR and crystal structures to understand its role in activation and inhibition.