Marianne Schimpl

This study develops D-box peptides that inhibit APC/C by binding Cdc20, showing they are more potent than Apcin and can drive protein degradation.

This study evaluates BI9774, an AMPK activator, in a mouse model of NASH, finding it reduces liver steatosis but not fibrosis and causes cardiac side effects.

This study investigates the dynamics of the HD subdomain in PARP-1 using NMR and crystal structures to understand its role in activation and inhibition.