Discovery of cephalotaxinone enzymes reveals a whole plant model for homoharringtonine biosynthesis
Yaereen Dho, Kevin Smith, Elizabeth S. Sattely
The paper identifies seven pathway intermediates and six novel enzymes involved in the biosynthesis of homoharringtonine (HHT) in Cephalotaxus plants, revealing a whole-plant coordination model for its production.
bioRxiv · Aug 26, 2025 · PreprintBiochemistry