Elizabeth S. Sattely

Microbiota- and diet-specific T cells become Tregs by default

The paper shows that T cells specific for microbiota and diet antigens predominantly become regulatory T cells (iTregs) in the gut, with effector responses emerging only under specific inflammatory and genetic conditions.

FoTO1 orchestrates Taxol biosynthesis through catalytic and non-catalytic mechanisms

This paper identifies FoTO1 as a dual-function enzyme that enhances Taxol biosynthesis through catalytic conversion and non-catalytic organization of P450s in plants.

Identification and characterization of dietary antigens in oral tolerance

The paper identifies seed storage protein epitopes as targets of intestinal regulatory T cells that modulate immune responses to dietary antigens.

Discovery of cephalotaxinone enzymes reveals a whole plant model for homoharringtonine biosynthesis

The paper identifies seven pathway intermediates and six novel enzymes involved in the biosynthesis of homoharringtonine (HHT) in Cephalotaxus plants, revealing a whole-plant coordination model for its production.

An in planta single-cell screen to accelerate functional genetics

The paper introduces a single-cell screening platform called PIVOT for functional genetics in plants, demonstrating its ability to identify cytokinin signaling regulators.

Multiplexed perturbation of yew reveals cryptic proteins that enable a total biosynthesis of baccatin III and Taxol precursors

A multiplexed perturbation and single-nucleus RNA-seq screen of Taxus needles found eight new Taxol pathway genes, including FoTO1, enabling baccatin III and a late Taxol precursor in N. benthamiana.

Transcriptome analysis reveals role for WRKY70 in early N-hydroxy-pipecolic acid signaling

This study identifies WRKY70's role in NHP-induced transcriptional responses and shows SA dependency in early plant immunity.

Zinc-starved Brassicaceae Plants Secrete Peptides thatInduce Root Expansion

This study identifies secreted peptides in zinc-deficient Brassicaceae plants that promote root expansion to enhance zinc uptake.

Gut microbiota gate host exposure to cholinesterase inhibitors from dietary Solanums

The paper investigates how gut microbiota modify steroidal alkaloids from Solanum plants, affecting host exposure and physiological effects.

HEx: a heterologous expression platform for the discovery of fungal natural products

A yeast-based refactoring platform (HEx) with new inducible promoters, an engineered host strain, and homology-based assembly expressed 41 cryptic fungal gene clusters; 22 yielded non-native compounds.