Conditional polygenic enrichment distinguishes causal from tagging disease-critical cell populations in single-cell RNA-seq
Alistair Turcan, Kangcheng Hou, Kevin Z. Lin, Andreas R. Pfenning, Saori Sakaue, Martin Jinye Zhang
This paper introduces scDRS-FM, a method to distinguish causal from tagging disease associations in scRNA-seq data, showing it improves power and accuracy in identifying disease-relevant cell populations.
medRxiv · Aug 23, 2026 · PreprintGenetic & Genomic Medicine