Katherine E. Prater

The paper investigates how pregnancy history and PSEN2 deficiency affect cognitive function and neurobiology in aged female mice, finding no synergistic effects.

GeoAdvAE integrates unpaired single-cell morphology and transcriptomics to align cell types and reveal disease-associated microglia signatures.

This study creates a multi-modal atlas of choroid plexus pathology across aging and Alzheimer's disease, identifying fibrosis, calcification, and macrophage abnormalities as key features.

This study shows that genetic risk variants in endolysosomal network genes correlate with endolysosomal dysfunction in neural cells in Alzheimer's disease.

The paper identifies transcriptomically distinct microglia populations in Alzheimer's disease and aged human brains using single-nucleus RNA-seq and trajectory inference.