Author

Shannon E. Rose

University of Washington

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Neuroscience· 6

Signature Assays, Organisms & Methods

Click to filter · or open tag

Organism:human· 5 Research Focus:differential expression· 3 Approach:experimental assay· 3 Approach:statistical model· 3 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 1 Research Focus:clustering· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

Jessica E. YoungiD· 6 shared Suman JayadeviD· 4 shared Aquene N. ReidiD· 3 shared Alexandra CochoitiD· 2 shared C. Andrew Williams· 2 shared Elizabeth BlueiD· 2 shared Gwenn A. GardeniD· 2 shared Jesse C. WileyiD· 2 shared

Activity by Year

2022-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 38 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

6 shared papersNeuroscience

Jessica E. YoungORCID

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

The Alzheimer's disease risk gene SORL1 is a regulator of excitatory neuronal function

C. Andrew Williams, Shannon E. Rose, Vera Stamenković, Aquene N. Reid, Kyle J. Travaglini, Stephen E.P. Smith, Jessica E. Young

This study shows that SORL1 deficiency in neurons alters synaptic protein interactions, causes hyperexcitability, and impairs synaptic plasticity, linking endosomal recycling defects to Alzheimer's disease pathogenesis.

Alzheimer s & Dementia · Sep 1, 2026Peer-reviewedNeuroscience

Kat5 cKO Biological Domain Signatures Align with Human Alzheimer Disease

Gregory A. Cary, Jessica E. Young, Shannon E. Rose, Harald Frankowski, Martin Darvas, Mark Bothwell, Suman Jayadev, Aquene N. Reid, Anna K. Greenwood, Allan I. Levey, Karina Leal, Gregory W. Carter, Jesse C. Wiley

The paper compares the transcriptome of Kat5 knockout mice to AD datasets, finding similar gene expression patterns and showing KAT5 localization in AD neurons.

bioRxiv · Sep 13, 2025 · PreprintNeuroscience

Genetic risk implicating endolysosomal network genes correlates with endolysosomal dysfunction across neural cell types in Alzheimer's disease

Shannon E. Rose, Katherine E. Prater, Sainath Mamde, Isabelle Smith, Yu Fan Lin, Alexandra Cochoit, Aquene N. Reid, Corbin S.C. Johnson, Wei Qiu, Samuel D. Strohbehn, Catilin S. Latimer, C. Dirk Keene, Su‐In Lee, Kevin Z. Lin, Bradley A. Rolf, , Suman Jayadev

This study shows that genetic risk variants in endolysosomal network genes correlate with endolysosomal dysfunction in neural cells in Alzheimer's disease.

bioRxiv · Mar 16, 2025 · PreprintNeuroscience

A familial missense variant in the Alzheimer's Disease gene SORL1 impairs its maturation and endosomal sorting.

Elnaz Fazeli, Daniel D. Child, Stephanie A. Bucks, Miki Stovarsky, Gabrielle Edwards, Shannon E. Rose, Chang‐En Yu, Caitlin S. Latimer, Yu Kitago, Thomas D. Bird, Suman Jayadev, Olav M. Andersen, Jessica E. Young

The paper identifies a pathogenic SORL1 variant, p.R953C, associated with Alzheimer's Disease and shows it impairs protein maturation and endosomal sorting.

Acta Neuropathologica · Jan 20, 2024Peer-reviewedNeuroscience

Transcriptomically unique endolysosomal and homeostatic microglia populations in Alzheimer's disease and aged human brain

Katherine E. Prater, Kevin J. Green, Sainath Mamde, Wei Sun, Alexandra Cochoit, C S Smith, Kenneth L. Chiou, Laura M. Heath, Shannon E. Rose, Jesse C. Wiley, Christopher Dirk Keene, Ronald Young Kwon, Noah Snyder‐Mackler, Elizabeth Blue, Benjamin A. Logsdon, , Suman Jayadev

The paper identifies transcriptomically distinct microglia populations in Alzheimer's disease and aged human brains using single-nucleus RNA-seq and trajectory inference.

Nature Aging · May 29, 2023Peer-reviewedNeuroscience

Pharmacologic Stabilization of Retromer Rescues Endosomal Pathology Induced by Defects in the Alzheimer's gene SORL1

Swati Mishra, Allison Knupp, Chizuru Kinoshita, C. Andrew Williams, Shannon E. Rose, Refugio A. Martinez, Panos Theofilas, Jessica E. Young

The paper tests if a retromer stabilizing drug, TPT-260, can correct endosomal and Alzheimer's-related pathologies in neurons with SORL1 variants.

bioRxiv · Jul 31, 2022 · PreprintNeuroscience