Developmental Timing Establishes Hematopoietic Stem and Progenitor Cell Lineage Bias
Anastasia Nizhnik, Bianca A. Ulloa, Kevyn Jackson, Deyou Zheng, Teresa Venezia Bowman
The paper uses zebrafish developmental lineage tracing and single-cell RNA sequencing to show that early HSPCs favor lymphoid lineage while later HSPCs skew towards erythroid, with early HSPCs contributing to adult lymphocytes.
bioRxiv · May 12, 2025 · PreprintDevelopmental Biology