Chemical modulation of the unfolded protein response reveals an antiviral role for the PERK pathway in human coronavirus 229E infection
Isabella E. Pellizzari-Delano, Trinity H. Tooley, Debanjana Mondal, Keya Jani, Carla E. Gallardo-Flores, Che C. Colpitts
This study identifies PERK pathway activation as an antiviral mechanism against HCoV-229E and SARS-CoV-2 through chemical modulation of the unfolded protein response.
RSC Chemical Biology · Jan 1, 2026Peer-reviewedMicrobiology