Author
Queen's UniversityORCID 0009-0009-7978-5069Unclaimed ORCID profile · follow to get notified of new preprints
3 papers
Recent·Most cited
Trinity H. Tooley, Abbey J. McMurray, Isabella E. Pellizzari-Delano, Che C. Colpitts
This study shows that thapsigargin inhibits HCV infection by modulating lipid metabolism, affecting both RNA replication and viral egress through distinct mechanisms.
Isabella E. Pellizzari-Delano, Trinity H. Tooley, Debanjana Mondal…·Che C. Colpitts
This study identifies PERK pathway activation as an antiviral mechanism against HCoV-229E and SARS-CoV-2 through chemical modulation of the unfolded protein response.
Brett A. Duguay, Trinity H. Tooley, Eric S. Pringle…·Craig McCormick
This paper develops a yeast-based reverse genetics system to generate HCoV-OC43 reporter viruses with an eighth sgRNA, enabling modular genome assembly and mutagenesis.