Modifications of the 22A apoA-I mimetic peptide sequence improve the anti-atherosclerotic properties of synthetic HDL
Sirine Nouri, Laura Giorgi, Akseli Niemelä, Juho Heininen, Khalfa Benadouda, Sagar Dhakal, Artturi Koivuniemi
This study modifies the 22A apoA-I mimetic peptide sequence to enhance cholesterol efflux and LCAT activity in synthetic HDL, without affecting plasma HDL remodeling.
bioRxiv · Aug 13, 2025 · PreprintPharmacology & Toxicology