Sirine Nouri

This paper investigates peptide nanodisc structure and dynamics using NMR, SAS, and MD simulations, revealing polydispersity, helical configuration, and lipid-rotation insights.

This study modifies the 22A apoA-I mimetic peptide sequence to enhance cholesterol efflux and LCAT activity in synthetic HDL, without affecting plasma HDL remodeling.

The paper identifies gliflozins, sucrose, and flavonoids as activators of LCAT using in silico predictions and in vitro assays, highlighting their potential in treating LCAT deficiency and atherosclerosis.