Akseli Niemelä

Exploring Peptide-Based Nanodiscs Structure and Dynamics through Synergistic Approach of NMR Spectroscopy, SAS and MD Simulations

This paper investigates peptide nanodisc structure and dynamics using NMR, SAS, and MD simulations, revealing polydispersity, helical configuration, and lipid-rotation insights.

Modifications of the 22A apoA-I mimetic peptide sequence improve the anti-atherosclerotic properties of synthetic HDL

This study modifies the 22A apoA-I mimetic peptide sequence to enhance cholesterol efflux and LCAT activity in synthetic HDL, without affecting plasma HDL remodeling.

Gliflozins, sucrose and flavonoids are allosteric activators of lecithin:cholesterol acyltransferase

The paper identifies gliflozins, sucrose, and flavonoids as activators of LCAT using in silico predictions and in vitro assays, highlighting their potential in treating LCAT deficiency and atherosclerosis.

Systematic Evaluation of Lecithin:Cholesterol Acyltransferase Binding Sites in Apolipoproteins via Peptide Based Nanodiscs: Regulatory Role of Charged Residues at Positions 4 and 7

This study identifies molecular determinants of LCAT binding to apolipoproteins using simulations, revealing key residues that influence LCAT activity on different lipoproteins.