Efficient exploration of sequence space enables rapid generation of functional genome editors
Nicholas W. Hughes, Sourab Kulkarni, Grant Goldman, Júlia Daher Carneiro Marsiglia, Sunit Jain, Kaitlyn K. Spees, Becky Xu Hua Fu, Kia Vaalavirta, Muneaki Nakamura
The paper generates functional genome editors by combining deep mutational scanning, structural analysis, and evolutionary mining with a generative protein language model.
bioRxiv · Aug 20, 2026 · PreprintSynthetic Biology