Becky Xu Hua Fu

Efficient exploration of sequence space enables rapid generation of functional genome editors

The paper generates functional genome editors by combining deep mutational scanning, structural analysis, and evolutionary mining with a generative protein language model.

The regulation of Protein Phosphatase 4 by FBXO42 is required for cancer cell survival.

This study identifies FBXO42's role in regulating PPP4C and p53 signaling, showing its importance in cancer cell survival through genetic and proteomic analyses.

Genome-wide CRISPR screens identify PTGES3 as a novel AR modulator

This study uses CRISPR screens to identify PTGES3 as a novel modulator of AR protein levels and function in prostate cancer, showing its role in therapy resistance.

Loss of Fanconi anemia proteins causes a reliance on lysosomal exocytosis

This study identifies a dependency on lysosomal exocytosis in FA pathway-deficient cells and tumors, revealing a new therapeutic target for FA-related cancers.

Genome-wide quantification of RNA flow across subcellular compartments reveals determinants of the mammalian transcript life cycle

The paper quantifies RNA flow across subcellular compartments using TimeLapse-seq and identifies factors influencing mRNA life cycles.