Nicholas W. Hughes

This study identifies CXCL-CXCR2 signaling as critical for SCLC liver metastasis by enhancing cancer cell migration and interactions with endothelial cells.

The paper generates functional genome editors by combining deep mutational scanning, structural analysis, and evolutionary mining with a generative protein language model.

The paper identifies HBO1 and MLL1 complexes as key tumor suppressors in lung cancer using in vivo functional screens of epigenetic regulators.

This study develops transgenic Cas12a mice to enable efficient, multiplexed somatic genome editing for studying complex genetic interactions in vivo.

This study uses protein language models and high-throughput screening to engineer an anti-CRISPR protein that enhances CRISPR/Cas genome editing precision in human cells.