Muneaki Nakamura

The paper generates functional genome editors by combining deep mutational scanning, structural analysis, and evolutionary mining with a generative protein language model.

This study uses protein language models and high-throughput screening to engineer an anti-CRISPR protein that enhances CRISPR/Cas genome editing precision in human cells.

The paper describes a reporter system to quantify durable CRISPR-based gene silencing and reports a single CRISPR protein capable of producing long-lasting gene repression.