Therapeutic benefits of maintaining CDK4/6 inhibitors and incorporating CDK2 inhibitors beyond progression in breast cancer
Jessica Armand, Sungsoo Kim, Kibum Kim, Eugene Son, Minah Kim, Kevin M. Kalinsky, Hee Won Yang
This study shows that continuing CDK4/6 inhibitors and adding CDK2 inhibitors slows growth of drug-resistant breast cancer by delaying cell cycle progression and reducing E2F transcription.
eLife · Dec 29, 2025Peer-reviewedCancer Biology