Pulses of Class I PI3kinase activity identify the release and recapture of prey from neutrophil phagosomes
Clare F. Muir, Constantino Carlos Reyes‐Aldasoro, Tomasz K. Prajsnar, Bartosz J. Michno, Justyna Cholewa-Waclaw, Yin Xin Ho, Audrey Bernut, Catherine A. Loynes, Stone Elworthy, Kieran A. Bowden, Ashley J. Cadby, Lynne R. Prince, Jason King, Felix E. Ellett, Alison Mary Condliffe, Stephen A. Renshaw
The paper identifies pulsatile Class I PI3K activity on neutrophil phagosomes during bacterial infection, suggesting phagosomes reopen and reclose to release or restart digestion.
Disease Models & Mechanisms · Jul 22, 2025Peer-reviewedCell Biology