Preventing trogocytosis by cathepsin B inhibition augments CAR T cell function
Kenneth A. Dietze, Kiet Nguyen, Aashli Pathni, F. Fazekas, Wenxiang Sun, Ethan Rosati, Jillian M. Baker, Maday Galeana Figueroa, Etse Gebru, Daniel Yamoah, Rediet Mulatu, Alexander Wang, Aaron P. Rapoport, David Henry Lum, Xiaoxuan Fan, , Tim Luetkens
This study shows that inhibiting cathepsin B prevents CAR T cell fratricide and exhaustion by blocking trogocytosis, improving CAR T cell persistence and anti-tumor activity.
Signal Transduction and Targeted Therapy · Apr 22, 2026Peer-reviewedBioengineering