BioengineeringSignal Transduction and Targeted TherapyPeer-reviewed
Preventing trogocytosis by cathepsin B inhibition augments CAR T cell function
Kenneth A. Dietze, Kiet Nguyen, Aashli Pathni…·Tim Luetkens
This study shows that inhibiting cathepsin B prevents CAR T cell fratricide and exhaustion by blocking trogocytosis, improving CAR T cell persistence and anti-tumor activity.
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