Xiaoxuan Fan

This study shows that inhibiting cathepsin B prevents CAR T cell fratricide and exhaustion by blocking trogocytosis, improving CAR T cell persistence and anti-tumor activity.

OPTRACE improves cell transplantation and tracking in the mouse brain using real-time visualization and longitudinal monitoring to study engraftment dynamics.

This study shows that inhibiting autophagy-lysosomal function worsens lipid metabolism reprogramming and dysfunction in microglia and monocytes after brain injury.

This study uses single-nucleus RNA sequencing to analyze CSF leukocytes after IVH, identifying distinct immune cell states and signaling networks involved in inflammation.

The paper shows that modifying integrin-mediated adhesion in CAR T cells prevents CNS targeting while maintaining anti-tumor activity against Ewing sarcoma.