David Henry Lum

Lean breast adipocytes secrete an oxylipin that suppresses breast cancer via ferroptosis

The paper identifies 9S-HODE, a lipid secreted by lean adipocytes, as a ferroptosis inducer that suppresses breast cancer while sparing normal cells, with therapeutic potential in obese mice.

SWI/SNF Alterations Define a Chromatin-Dependent Subtype of Urothelial Carcinoma

This paper identifies a chromatin-altered subtype of urothelial carcinoma defined by SWI/SNF alterations, showing it is sensitive to HDAC inhibition and immunotherapy.

Defining biologically directed therapy target signatures in urothelial carcinoma: A transcriptomic framework for precision therapy

This paper identifies biologically distinct transcriptomic and proteomic patterns of ADC and immunotherapy targets in urothelial carcinoma, linking them to histologic and molecular subtypes for precision therapy.

Preventing trogocytosis by cathepsin B inhibition augments CAR T cell function

This study shows that inhibiting cathepsin B prevents CAR T cell fratricide and exhaustion by blocking trogocytosis, improving CAR T cell persistence and anti-tumor activity.

Receptor tyrosine kinase inhibition leads to regression of acral melanoma by targeting the tumor microenvironment

This study shows that dual FGFR/VEGFR inhibition causes regression of acral melanoma by targeting the tumor microenvironment rather than directly killing cancer cells.

Zinc Alpha-2-Glycoprotein (ZAG/AZGP1) secreted by triple-negative breast cancer promotes tumor microenvironment fibrosis.

This study identifies ZAG/AZGP1 as a secreted factor from triple-negative breast cancer cells that promotes fibrosis in the tumor microenvironment and is linked to poor patient prognosis.