Overexpression of a non-muscle RBFOX2 isoform triggers cardiac conduction defects in myotonic dystrophy
Chaitali Misra, Sushant Bangru, Feikai Lin, Kin Lok H. Lam, Sara N. Koenig, Ellen R. Lubbers, Jamila Hedhli, Nathaniel P. Murphy, Darren J. Parker, Lawrence W. Dobrucki, Thomas A. Cooper, Emad Tajkhorshid, Peter J. Mohler, Auinash Kalsotra
This study identifies overexpression of a non-muscle RBFOX2 isoform as a cause of cardiac conduction defects in myotonic dystrophy by inducing arrhythmia and altering ion channel splicing.
Developmental Cell · Feb 27, 2020Peer-reviewedGenetics