TR-107, a novel mitochondrial ClpP agonist, induces robust antitumor activity against preclinical models of adrenocortical carcinoma
George I Karadimov, Yoo Sun Kim, Haiqing Fu, Sidhant Narula, Fathi Elloumi, Anjali Dhall, Frank Echtenkamp, Luowei Li, Edwin J. Iwanowicz, Lee M. Graves, King Chan, Þorkell Andrésson, Robert W. Robey, Yoshimi Endo Greer, Stanley Lipkowitz, , Jaydira Del Rivero
This study evaluates TR-107, a mitochondrial ClpP agonist, showing antitumor effects in ACC cell lines and organoids, with synergistic activity when combined with IGF-1R inhibitors.
bioRxiv · Aug 11, 2026 · PreprintCancer Biology