Author

Yoo Sun Kim

National Cancer InstituteORCID 0000-0002-6474-9024Unclaimed ORCID profile · follow to get notified of new preprints

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:database / resource· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Fathi ElloumiiD· 3 shared Anjali DhalliD· 2 shared Daiki TaniyamaiD· 2 shared Jaydira Del RiveroiD· 2 shared Mirit I. AladjemiD· 2 shared Nitin RoperiD· 2 shared Robert W. RobeyiD· 2 shared Suresh KumariD· 2 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 40 mutual co-author links

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3 shared papersCancer Biology

Fathi ElloumiORCID

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3 papers

Recent·Most cited

Dynamic Schlafen 11 (SLFN11) expression revealed by single-cell RNA sequencing of clonal human cancer cells

Daiki Taniyama, Yoshitaka Inoue, Fathi Elloumi, Yoo Sun Kim, Nitin Roper, Charlie Seibert, Michael C. Kelly, Alexei Lobanov, Mirit I. Aladjem, Augustin Luna, Yves Pommier

The paper uses single-cell RNA sequencing to show heterogeneous SLFN11 expression in cancer cells, linking it to stress response and genome maintenance.

bioRxiv · Oct 7, 2026 · PreprintCancer Biology

TR-107, a novel mitochondrial ClpP agonist, induces robust antitumor activity against preclinical models of adrenocortical carcinoma

George I Karadimov, Yoo Sun Kim, Haiqing Fu, Sidhant Narula, Fathi Elloumi, Anjali Dhall, Frank Echtenkamp, Luowei Li, Edwin J. Iwanowicz, Lee M. Graves, King Chan, Þorkell Andrésson, Robert W. Robey, Yoshimi Endo Greer, Stanley Lipkowitz, , Jaydira Del Rivero

This study evaluates TR-107, a mitochondrial ClpP agonist, showing antitumor effects in ACC cell lines and organoids, with synergistic activity when combined with IGF-1R inhibitors.

bioRxiv · Aug 11, 2026 · PreprintCancer Biology

Identification of DLK1, a Notch ligand, as an immunotherapeutic target and regulator of tumor cell plasticity and chemoresistance in adrenocortical carcinoma

Nai-Yun Sun, Suresh Kumar, Yoo Sun Kim, Diana Grace Varghese, Arnulfo Mendoza, Rosa Nguyen, Reona Okada, Karlyne M. Reilly, Brigitte C. Widemann, Yves G. Pommier, Fathi Elloumi, Anjali Dhall, Daiki Taniyama, Mayank Patel, Etan R. Aber, , Nitin Roper

This paper identifies DLK1 as a novel immunotherapeutic target in adrenocortical carcinoma, showing it regulates tumor cell plasticity and chemoresistance, and demonstrates the efficacy of a DLK1-targeting antibody-drug conjugate.

Nature Communications · Jul 1, 2025Peer-reviewedCancer Biology