Cancer BiologybioRxivPreprint
TR-107, a novel mitochondrial ClpP agonist, induces robust antitumor activity against preclinical models of adrenocortical carcinoma
George I Karadimov, Yoo Sun Kim, Haiqing Fu…·Jaydira Del Rivero
This study evaluates TR-107, a mitochondrial ClpP agonist, showing antitumor effects in ACC cell lines and organoids, with synergistic activity when combined with IGF-1R inhibitors.
DOI 10.64898/2026.08.10.743339