SGLT2 inhibitors activate pantothenate kinase in the human heart
Nicholas Forelli, Trace Thome, Deborah Eaton, Kollin C. Schultz, Jiten D. Patel, Caitlyn E. Bowman, Ryo Kawakami, Jae Woo Jung, Ivan A. Kuznetsov, Kristina Li, Jialiu A. Liang, Kirsten Branch, Claire Brady, Kenneth C Bedi, Yijun Yang, , Zoltan Pierre Arany
This study identifies that SGLT2 inhibitors activate pantothenate kinase 1 (PANK1) in the human heart, enhancing coenzyme-A synthesis and fuel use, which may explain their clinical benefits in heart failure.
Science · Aug 27, 2026Peer-reviewedBiochemistry