Kollin C. Schultz

This study identifies that SGLT2 inhibitors activate pantothenate kinase 1 (PANK1) in the human heart, enhancing coenzyme-A synthesis and fuel use, which may explain their clinical benefits in heart failure.

The paper reports the cryo-EM structure of a fungal class II terpene synthase cyclase domain and shows substrate channeling between its prenyltransferase and cyclase functions.

This study shows that substrate channeling in PaFS occurs without a flexible linker or covalent domain linkage, and that cyclase domains associate with the prenyltransferase octamer for optimal channeling.

This study shows that DIMT1's non-catalytic function is essential for AML proliferation and identifies a target region for therapeutic intervention.