Repression of the Wnt pathway effector TCF7L2 reverses lethal cachexia in mice with intestinal cancers
Mei Ling Leong, Christiane Ruedl, Klaus Karjalainen
This study shows that reducing TCF7L2 expression in mice with intestinal cancers reverses cachexia by restoring muscle mass and preventing weight loss.
bioRxiv · Nov 22, 2024 · PreprintCancer Biology