Christiane Ruedl

Gut microbiota-derived GlcNAc-MurNAc is a TLR4 agonist that protects the host gut

The paper identifies GlcNAc-MurNAc (GM) as a TLR4 agonist derived from gut microbiota that reduces colonic inflammation in mice.

The synovial lining macrophage layer develops in the first weeks of life in a CSF1- and TGFβ- dependent but monocyte-independent process.

The paper identifies CSF1 and TGFβ as key signals for synovial lining macrophage development in mice, which occurs postnatally and is monocyte-independent.

Repression of the Wnt pathway effector TCF7L2 reverses lethal cachexia in mice with intestinal cancers

This study shows that reducing TCF7L2 expression in mice with intestinal cancers reverses cachexia by restoring muscle mass and preventing weight loss.

Mitochondrial control of microglial phagocytosis in Alzheimer's disease

This study shows that TSPO regulates mitochondrial metabolism and phagocytosis in microglia, and that targeting mitochondrial HK could improve phagocytosis in Alzheimer's disease.

Islet macrophages drive islet remodeling and compensatory hyperinsulinemia in the early diabetes

The paper shows that islet resident macrophages drive islet remodeling and hyperinsulinemia in early type-2 diabetes by promoting vascularization and insulin secretion.