Macrophage extracellular traps promote maladaptive cardiac remodelling and heart failure via PAD4-dependent mechanisms
Shohei Ichimura, Tomofumi Misaka, Satoshi Okochi, Ryo Ogawara, Yuichi Sato, Shunsuke Miura, Tetsuro Yokokawa, Saori Miura, Koki Ueda, Masayoshi Oikawa, Akiomi Yoshihisa, Kazuhiko Ikeda, Takafumi Ishida, Yasuchika Takeishi
This study shows that macrophage extracellular traps (METs) contribute to heart failure by promoting cardiac remodelling through PAD4-dependent mechanisms, and targeting METs may offer therapeutic potential.
bioRxiv · Mar 18, 2026 · PreprintPathology